In most cases, higher bilirubin levels will lead to jaundice between 1 and 3 days after birth. A newborn’s liver is only about 1% as active as an adult’s. It happens because newborns have more red blood cells and break them down more quickly, but their livers are not developed enough to keep up.īefore being born, the pregnant person’s liver helps with this task. This temporary condition usually resolves on its own within a few weeks. Many babies have high bilirubin a few days after birth, causing newborn jaundice. It’s sometimes passed down genetically, but autoimmune conditions, an enlarged spleen, or an infection can also cause it. Hemolytic anemia: This happens when blood cells break down too quickly in your bloodstream. This makes it harder for your liver to process bilirubin from your blood, leading to high bilirubin levels. It causes bile drainage from your liver to either slow down or stop entirely. Intrahepatic cholestasis of pregnancy: This is a temporary condition during the last trimester of pregnancy.This can lead to an increased level of bilirubin. Bile can’t be drained adequately if these ducts become inflamed or blocked. They help to move bile, which contains bilirubin, from your liver and gallbladder into your intestines. Bile duct obstruction: Bile ducts connect your liver to your gallbladder and the opening of your small intestine, called the duodenum.When it’s inflamed, your liver can’t easily process bilirubin, leading to a buildup of it in your blood. Hepatitis: This happens when your liver becomes inflamed, often due to a viral infection.Examples include cirrhosis, liver cancer, or autoimmune hepatitis. This is a result of your liver losing its ability to remove and process bilirubin from your bloodstream. Liver dysfunction: This can be any condition that affects the function of your liver and causes bilirubin to build up in your blood.This causes the bilirubin to build up in your bloodstream. Gilbert’s syndrome: This is a genetic liver condition that causes your liver not to process bilirubin properly.Your gallbladder stores bile, a digestive fluid that helps break down fats before they enter your intestines. Gallstones: These develop when substances like cholesterol or bilirubin harden in your gallbladder.Your doctor will take your symptoms, as well as any other test results, into account to help narrow down a diagnosis. Having high bilirubin can be a sign of several conditions.
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